Gene: ZMYND10
Alternate names for this Gene: BLU|CILD22|DNAAF7|FLU
Gene Summary: This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 3
Location in Chromosome : 3p21.31
Description of this Gene: zinc finger MYND-type containing 10
Type of Gene: protein-coding
rs138815960 in
ZMYND10 gene and
CILIARY DYSKINESIA, PRIMARY, 22
PMID 23891469 2013 ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.
PMID 23891471 2013 Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.
PMID 25186273 2014 Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.
PMID 29601588 2018 ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.
rs138815960 in
ZMYND10 gene and
Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus
PMID 23891471 2013 Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.
rs138815960 in
ZMYND10 gene and
Ciliary Motility Disorders
PMID 23891471 2013 Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.
PMID 23891469 2013 ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.