Gene: ZWINT

Alternate names for this Gene: HZwint-1|KNTC2AP|SIP30|ZWINT1

Gene Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 10

Location in Chromosome : 10q21.1

Description of this Gene: ZW10 interacting kinetochore protein

Type of Gene: protein-coding

rs2393069 in ZWINT gene and Scoliosis, unspecified PMID 22019779 2011 A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.