Variant: rs1057519729 

    present in Gene: MAP2K1
    present in Chromosome: 15
    Position on Chromosome: 66435113
    Alleles of this Variant: A/C

rs1057519729 in MAP2K1 gene and Non-Small Cell Lung Carcinoma PMID 7651428 1995 RAS signalling is abnormal in a c-raf1 MEK1 double mutant.

PMID 18632602 2008 We also screened 85 NSCLC cell lines for MEK1 exon 2 mutations; one line (NCI-H1437) harbors a Q56P substitution, a known transformation-competent allele of MEK1 originally identified in rat fibroblasts, and is sensitive to treatment with AZD6244.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs1057519729 in MAP2K1 gene and melanoma PMID 23569304 2013 Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma.

PMID 19915144 2009 MEK1 mutations confer resistance to MEK and B-RAF inhibition.