Variant: rs1057519732 

    present in Gene: MAP2K1
    present in Chromosome: 15
    Position on Chromosome: 66436824
    Alleles of this Variant: C/A;T

rs1057519732 in MAP2K1 gene and Colorectal Neoplasms PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519732 in MAP2K1 gene and Cutaneous Melanoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519732 in MAP2K1 gene and Malignant Uterine Corpus Neoplasm PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519732 in MAP2K1 gene and Transitional cell carcinoma of bladder PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519732 in MAP2K1 gene and melanoma PMID 19915144 2009 MEK1 mutations confer resistance to MEK and B-RAF inhibition.

PMID 22588879 2012 Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors.

PMID 22197931 2011 Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.