Variant: rs1057519742 

    present in Gene: GNA11
    present in Chromosome: 19
    Position on Chromosome: 3118944
    Alleles of this Variant: A/C;T

rs1057519742 in GNA11 gene and Cutaneous Melanoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519742 in GNA11 gene and Uveal melanoma PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 24141786 2014 Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.

PMID 21444680 2011 Therapeutic implications of the emerging molecular biology of uveal melanoma.

rs1057519742 in GNA11 gene and melanoma PMID 22808163 2012 Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.

PMID 2549426 1989 GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

PMID 1328859 1992 Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.

PMID 21083380 2010 Mutations in GNA11 in uveal melanoma.

PMID 22733540 2012 Activating Q209L/P mutations in GNAQ or GNA11 (GNAQ/11) are present in approximately 80% of uveal melanomas.