Variant: rs121913237 

    present in Gene: NRAS
    present in Chromosome: 1
    Position on Chromosome: 114716126
    Alleles of this Variant: C/A;G;T

rs121913237 in NRAS gene and Colorectal Neoplasms PMID 21305640 2011 Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.

PMID 21729679 2011 Development of molecular biomarkers in individualized treatment of colorectal cancer.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 20736745 2010 NRAS mutations are rare in colorectal cancer.

PMID 21829508 2011 PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers.

PMID 17699718 2007 AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models.

PMID 16273091 2006 BRAF mutation predicts sensitivity to MEK inhibition.

PMID 20619739 2010 Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

rs121913237 in NRAS gene and Cutaneous Melanoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913237 in NRAS gene and Gastric Adenocarcinoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913237 in NRAS gene and Juvenile Myelomonocytic Leukemia PMID 17332249 2007 Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

PMID 24493721 2014 American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.

rs121913237 in NRAS gene and Leukemia, Myelocytic, Acute PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 3122217 1987 RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes.

PMID 2278970 1990 RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study.

PMID 19075190 2009 High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.

PMID 19657110 2009 Recurring mutations found by sequencing an acute myeloid leukemia genome.

PMID 22144181 2012 Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 16434492 2006 Implications of NRAS mutations in AML: a study of 2502 patients.

PMID 22407852 2012 RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group.

rs121913237 in NRAS gene and MYELODYSPLASTIC SYNDROME PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913237 in NRAS gene and Malignant Uterine Corpus Neoplasm PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913237 in NRAS gene and Multiple Myeloma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913237 in NRAS gene and NEVUS, EPIDERMAL (disorder) PMID 22499344 2012 Keratinocytic epidermal nevi are associated with mosaic RAS mutations.

rs121913237 in NRAS gene and Non-Small Cell Lung Carcinoma PMID 23515407 2013 Characteristics of lung cancers harboring NRAS mutations.

PMID 18948947 2008 Somatic mutations affect key pathways in lung adenocarcinoma.

PMID 12460918 2002 BRAF and RAS mutations in human lung cancer and melanoma.

rs121913237 in NRAS gene and Noonan Syndrome PMID 14982869 2004 Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia.

PMID 15831708 2005 Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse.

PMID 15046639 2004 Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis.

PMID 18952898 2009 RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia.

rs121913237 in NRAS gene and melanoma PMID 16291983 2005 Distinct sets of genetic alterations in melanoma.

PMID 8120410 1994 Ras mutations in human melanoma: a marker of malignant progression.

PMID 20130576 2010 RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

PMID 18390968 2008 Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.

PMID 20179705 2010 RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

PMID 2674680 1989 N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

PMID 23414587 2013 MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.