Variant: rs121913492 

    present in Gene: GNAQ
    present in Chromosome: 9
    Position on Chromosome: 77794572
    Alleles of this Variant: T/A;C;G

rs121913492 in GNAQ gene and Uveal melanoma PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121913492 in GNAQ gene and melanoma PMID 22808163 2012 Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.

PMID 22253748 2012 The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma.

PMID 21083380 2010 Mutations in GNA11 in uveal melanoma.

PMID 19078957 2009 Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.

PMID 18719078 2008 Oncogenic mutations in GNAQ occur early in uveal melanoma.

PMID 1328859 1992 Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.

PMID 22733540 2012 Activating Q209L/P mutations in GNAQ or GNA11 (GNAQ/11) are present in approximately 80% of uveal melanomas.

PMID 2549426 1989 GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

PMID 22653968 2012 Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.