Variant: rs121913502 

    present in Gene: IDH2
    present in Chromosome: 15
    Position on Chromosome: 90088702
    Alleles of this Variant: C/A;T

rs121913502 in IDH2 gene and Colorectal Neoplasms PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913502 in IDH2 gene and D-2-HYDROXYGLUTARIC ACIDURIA 2 PMID 20847235 2010 IDH2 mutations in patients with D-2-hydroxyglutaric aciduria.

PMID 21889589 2011 A lymphoblast model for IDH2 gain-of-function activity in d-2-hydroxyglutaric aciduria type II: novel avenues for biochemical and therapeutic studies.

rs121913502 in IDH2 gene and Leukemia, Myelocytic, Acute PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 23815907 2013 There were 9 AML patients with R140Q mutation, 1 patient with R140W mutation, and 1 patient with R172K mutation.

PMID 22397365 2012 Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients.

PMID 23949315 2013 Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.

PMID 24606448 2014 Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 23558173 2013 Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.

PMID 22417203 2012 Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

PMID 20946881 2010 Intriguingly, the IDH2 mutation p.R140Q and novel IDH1 mutation p.I99M co-occurred in a 75-year-old patient with AML developed from myelodysplastic syndromes (MDS).

PMID 22160010 2011 Impact of genetic features on treatment decisions in AML.

rs121913502 in IDH2 gene and MYELODYSPLASTIC SYNDROME PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913502 in IDH2 gene and Multiple Myeloma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913502 in IDH2 gene and Squamous cell carcinoma of the head and neck PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.