Variant: rs121913504 

    present in Gene: JAK3
    present in Chromosome: 19
    Position on Chromosome: 17837200
    Alleles of this Variant: G/A

rs121913504 in JAK3 gene and Acute Megakaryocytic Leukemias PMID 16843266 2006 JAK3(A572V), JAK3(V722I), and JAK3(P132T) each transform Ba/F3 cells to factor-independent growth, and JAK3(A572V) confers features of megakaryoblastic leukemia in a murine model.

rs121913504 in JAK3 gene and Chronic myeloproliferative disorder PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 20385788 2010 CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms.

PMID 20372971 2011 Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor.

PMID 22271575 2012 Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.