Variant: rs137853011 

    present in Gene: CHEK2
    present in Chromosome: 22
    Position on Chromosome: 28695219
    Alleles of this Variant: G/A

rs137853011 in CHEK2 gene and Hereditary Breast and Ovarian Cancer Syndrome PMID 28495237 2017 Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.

PMID 29785153 2018 Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.

PMID 27798748 2017 Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.

PMID 26845104 2016 Improving performance of multigene panels for genomic analysis of cancer predisposition.

PMID 28135139 2017 Efforts Toward Consensus Variant Interpretation by Commercial Laboratories.

PMID 18571837 2008 Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.

PMID 25503501 2015 Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.

PMID 24506336 2014 Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory.

PMID 18085035 2007 Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.

PMID 18706089 2008 Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.

PMID 27621404 2016 Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.

PMID 22419737 2012 Response to DNA damage of CHEK2 missense mutations in familial breast cancer.

PMID 16914568 2006 CHEK2-positive breast cancers in young Polish women.

PMID 30152102 2018 Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations.

PMID 28981386 2017 Complexities of Variant Classification in Clinical Hereditary Cancer Genetic Testing.

PMID 16551709 2006 Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.

PMID 28727877 2017 Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women.

PMID 15649950 2005 Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

rs137853011 in CHEK2 gene and Malignant neoplasm of breast PMID 18085035 2007 Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.

PMID 22419737 2012 Response to DNA damage of CHEK2 missense mutations in familial breast cancer.

PMID 18571837 2008 Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.

PMID 15649950 2005 Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

rs137853011 in CHEK2 gene and Mammary Neoplasms PMID 16914568 2006 CHEK2-positive breast cancers in young Polish women.

PMID 16551709 2006 Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.

PMID 22419737 2012 Response to DNA damage of CHEK2 missense mutations in familial breast cancer.

PMID 27153395 2016 Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.

PMID 15649950 2005 Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

PMID 18085035 2007 Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.

PMID 18571837 2008 Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.

rs137853011 in CHEK2 gene and Neoplastic Syndromes, Hereditary PMID 27153395 2016 Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.

PMID 18571837 2008 Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.

PMID 27798748 2017 Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.

PMID 15649950 2005 Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

PMID 22419737 2012 Response to DNA damage of CHEK2 missense mutations in familial breast cancer.

PMID 16794575 2006 Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.