present in Gene: SMO
present in Chromosome: 7
Position on Chromosome: 129203569
Alleles of this Variant: C/T
rs143083812 in
SMO gene and
Osteoarthritis of hip
PMID 30374069 2018 Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10<sup>-12</sup>, p.Arg173Cys) and IL11 (rs4252548, frequency 2.08%, OR = 1.30, P = 2.1 × 10<sup>-11</sup>, p.Arg112His).