present in Gene: ABCG2
present in Chromosome: 4
Position on Chromosome: 88131171
Alleles of this Variant: G/C;T
rs2231142 in
ABCG2 gene and
Arthritis, Gouty
PMID 21768215 2011 Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
PMID 20884846 2010 Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
PMID 18834626 2008 Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.
PMID 25967671 2015 Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.
PMID 29453348 2018 ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study.
PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
PMID 25676789 2015 Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
PMID 30924126 2019 Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
PMID 21983786 2011 Identification of low-frequency variants associated with gout and serum uric acid levels.
rs2231142 in
ABCG2 gene and
Gout
PMID 30924126 2019 Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
PMID 29453348 2018 ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study.
PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
PMID 20884846 2010 Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
PMID 21768215 2011 Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
PMID 25967671 2015 Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese.
PMID 21983786 2011 Identification of low-frequency variants associated with gout and serum uric acid levels.
PMID 25676789 2015 Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
PMID 18834626 2008 Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.
rs2231142 in
ABCG2 gene and
Hyperuricemia
PMID 29453348 2018 Whereas the rs2231142 in ABCG2 gene had significant associations between gout and controls, between gout and hyperuricemia, and between hyperuricemia and controls (all p-values < 10<sup>-7</sup>), and the ORs were 4.34, 3.37 and 2.15 (all p-values < 0.001) after adjustment of potential confounders, respectively.
rs2231142 in
ABCG2 gene and
Kidney Failure, Chronic
PMID 30181573 2018 Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.
rs2231142 in
ABCG2 gene and
Uric acid measurement (procedure)
PMID 19503597 2009 We found that the minor allele for rs734553 in SLC2A9 has greater influence in lowering uric acid levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men compared to women.
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
PMID 18834626 2008 Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.
PMID 30181573 2018 Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.
PMID 25676789 2015 Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
PMID 25811787 2015 Modulation of genetic associations with serum urate levels by body-mass-index in humans.
PMID 30305239 2019 Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease.
PMID 29558500 2018 Genome-wide association analysis identifies multiple loci associated with kidney disease-related traits in Korean populations.
PMID 30924126 2019 Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
PMID 26902266 2016 Genome wide association study of uric acid in Indian population and interaction of identified variants with Type 2 diabetes.
PMID 31207883 2019 Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans.
PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
PMID 24513273 2014 The two independent SNPs rs11722228 and rs2231142 explained 1.03% and 1.09% of the total variation of UA levels, respectively.
PMID 21983786 2011 Identification of low-frequency variants associated with gout and serum uric acid levels.