Variant: rs34637584 

    present in Gene: LRRK2
    present in Chromosome: 12
    Position on Chromosome: 40340400
    Alleles of this Variant: G/A

rs34637584 in LRRK2 gene and Movement Disorders PMID 17200152 2007 Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

PMID 25330418 2014 Disease penetrance of late-onset parkinsonism: a meta-analysis.

PMID 18213618 2008 Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls.

PMID 24243757 2013 Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.

PMID 28103901 2017 Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.

PMID 16102999 2005 Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.

PMID 15541309 2004 Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

PMID 16157901 2005 LRRK2 gene in Parkinson disease: mutation analysis and case control association study.

rs34637584 in LRRK2 gene and PARKINSON DISEASE 8 (disorder) PMID 26251043 2015 Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.

PMID 18986508 2008 The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study.

PMID 15726496 2005 Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.

PMID 22575234 2012 Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis.

PMID 23279440 2013 EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease.

PMID 15680455 2005 Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.

rs34637584 in LRRK2 gene and Parkinson Disease PMID 21738487 2011 Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.

PMID 24842889 2014 Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.