Variant: rs377767404 

    present in Gene: RET
    present in Chromosome: 10
    Position on Chromosome: 43114488
    Alleles of this Variant: T/C

rs377767404 in RET gene and Medullary carcinoma of thyroid PMID 10490816 1999 The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.

rs377767404 in RET gene and Multiple Endocrine Neoplasia Type 1 PMID 10490816 1999 The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.

rs377767404 in RET gene and Multiple Endocrine Neoplasia Type 2a PMID 10490816 1999 The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.

rs377767404 in RET gene and Multiple Endocrine Neoplasia Type 2b PMID 10490816 1999 The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.

rs377767404 in RET gene and Multiple Endocrine Neoplasia, Type IV PMID 10490816 1999 The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.

rs377767404 in RET gene and Multiple endocrine neoplasia Type 2 PMID 17527003 2007 A family of multiple endocrine neoplasia type 2A (MEN 2A) with Cys630Tyr RET germline mutation: report of a case.

PMID 16053382 2005 Penetrance and clinical manifestations of non-hotspot germline RET mutation, C630R, in a family with medullary thyroid carcinoma.

PMID 25440022 2015 Twenty years of lesson learning: how does the RET genetic screening test impact the clinical management of medullary thyroid cancer?

PMID 9879991 1998 Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.

PMID 15523405 2004 Emergence of medullary thyroid carcinoma in a family with the Cys630Arg RET germline mutation.

PMID 14561794 2003 Early malignant progression of hereditary medullary thyroid cancer.

PMID 21054478 2011 RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC).

PMID 9223675 1997 Novel germline RET proto-oncogene mutations associated with medullary thyroid carcinoma (MTC): mutation analysis in Japanese patients with MTC.