Variant: rs6025 

    present in Gene: F5
    present in Chromosome: 1
    Position on Chromosome: 169549811
    Alleles of this Variant: C/T

rs6025 in F5 gene and Activated Protein C Resistance PMID 23188048 2013 A gene-centric analysis of activated partial thromboplastin time and activated protein C resistance using the HumanCVD focused genotyping array.

rs6025 in F5 gene and Cerebrovascular accident PMID 26908601 2016 Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.

rs6025 in F5 gene and Deep Vein Thrombosis PMID 26908601 2016 Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.

rs6025 in F5 gene and Hereditary Factor V Deficiency PMID 8164741 1994 Mutation in blood coagulation factor V associated with resistance to activated protein C.

PMID 7911872 1994 Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V.

PMID 7910348 1994 Activated protein C resistance caused by Arg506Gln mutation in factor Va.

rs6025 in F5 gene and Inflammatory Bowel Diseases PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs6025 in F5 gene and Ischemic stroke PMID 26908601 2016 Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.

rs6025 in F5 gene and Peripheral Arterial Diseases PMID 31285632 2019 Genome-wide association study of peripheral artery disease in the Million Veteran Program.

rs6025 in F5 gene and Pulmonary Embolism PMID 26908601 2016 Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.

rs6025 in F5 gene and THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) PMID 21116184 2011 Factor V Leiden thrombophilia.

PMID 23900608 2013 Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.

rs6025 in F5 gene and Venous Thromboembolism PMID 28373160 2017 Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.

PMID 21980494 2011 Genetics of venous thrombosis: insights from a new genome wide association study.

PMID 22672568 2012 However, F5 was the main signal on 1q24.2 as only ABO SNPs remained significantly associated with VTE after adjusting for F5 rs6025.

PMID 31420334 2019 Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.

PMID 25772935 2015 Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

PMID 31676865 2019 We developed a genome-wide polygenic risk score for venous thromboembolism that identifies 5% of the population at an equivalent incident venous thromboembolism risk to carriers of the established factor V Leiden p.R506Q and prothrombin G20210A mutations.

PMID 26908601 2016 Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.

rs6025 in F5 gene and Venous Thrombosis PMID 22675575 2012 Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis.