present in Gene: PDGFRA
present in Chromosome: 4
Position on Chromosome: 54258293
Alleles of this Variant: C/T
rs7677751 in
PDGFRA gene and
Astigmatism
PMID 22144915 2011 Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.
rs7677751 in
PDGFRA gene and
Corneal Topography
PMID 23401653 2013 A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.
rs7677751 in
PDGFRA gene and
Regular astigmatism - corneal
PMID 22144915 2011 Variants in PDGFRA on chromosome 4q12 (lead SNP: rs7677751, allelic odds ratio = 1.26 (95% CI: 1.16-1.36), P(meta) = 7.87×10(-9)) were identified to be significantly associated with corneal astigmatism, exhibiting consistent effect sizes across all five cohorts.