Condition: Toxic Epidermal Necrolysis


rs5010528 in HLA-B;HLA-C gene and Toxic Epidermal Necrolysis PMID 28062682 2017 The most promising signal was seen in SJS/TEN, where rs5010528 ( HLA-C locus) approached genome-wide significance ( P  <   8.5 × 10 -8 ) and was below HLA -wide significance ( P  <   2.5 × 10 -4 ) in the meta-analysis of discovery and replication cohorts [OR 4.84 (95% CI 2.71-8.61)]. rs5010528 is a strong proxy for HLA-C*04:01 carriage: in silico docking showed that two residues (33 and 123) in the B pocket were the most likely nevirapine interactors.

rs9469003 in LINC01149 gene and Toxic Epidermal Necrolysis PMID 21801394 2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.

rs16957893 in LOC107984728 gene and Toxic Epidermal Necrolysis PMID 28100913 2017 Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications.

rs3130501 in POU5F1 gene and Toxic Epidermal Necrolysis PMID 21801394 2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.

rs3094188 in POU5F1;PSORS1C3 gene and Toxic Epidermal Necrolysis PMID 21801394 2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.

rs3815087 in PSORS1C1 gene and Toxic Epidermal Necrolysis PMID 21801394 2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.

rs2734583 in SNORD117;ATP6V1G2-DDX39B;DDX39B gene and Toxic Epidermal Necrolysis PMID 21912425 2013 A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.

rs3130931 in TCF19;POU5F1 gene and Toxic Epidermal Necrolysis PMID 21801394 2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.

rs17137412 in UMAD1 gene and Toxic Epidermal Necrolysis PMID 21221126 2012 Genome-wide association study of serious blistering skin rash caused by drugs.