Condition: Toxic Epidermal Necrolysis
rs5010528
in
HLA-B;HLA-C
gene and
Toxic Epidermal Necrolysis
PMID 28062682
2017 The most promising signal was seen in SJS/
TEN
, where
rs5010528
( HLA-C locus) approached genome-wide significance ( P < 8.5 × 10 -8 ) and was below HLA -wide significance ( P < 2.5 × 10 -4 ) in the meta-analysis of discovery and replication cohorts [OR 4.84 (95% CI 2.71-8.61)].
rs5010528
is a strong proxy for HLA-C*04:01 carriage: in silico docking showed that two residues (33 and 123) in the B pocket were the most likely nevirapine interactors.
rs9469003
in
LINC01149
gene and
Toxic Epidermal Necrolysis
PMID 21801394
2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.
rs16957893
in
LOC107984728
gene and
Toxic Epidermal Necrolysis
PMID 28100913
2017 Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications.
rs3130501
in
POU5F1
gene and
Toxic Epidermal Necrolysis
PMID 21801394
2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.
rs3094188
in
POU5F1;PSORS1C3
gene and
Toxic Epidermal Necrolysis
PMID 21801394
2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.
rs3815087
in
PSORS1C1
gene and
Toxic Epidermal Necrolysis
PMID 21801394
2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.
rs2734583
in
SNORD117;ATP6V1G2-DDX39B;DDX39B
gene and
Toxic Epidermal Necrolysis
PMID 21912425
2013 A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
rs3130931
in
TCF19;POU5F1
gene and
Toxic Epidermal Necrolysis
PMID 21801394
2011 Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.
rs17137412
in
UMAD1
gene and
Toxic Epidermal Necrolysis
PMID 21221126
2012 Genome-wide association study of serious blistering skin rash caused by drugs.