Gene: ABCG1

Alternate names for this Gene: ABC8|WHITE1

Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.

Gene is located in Chromosome: 21

Location in Chromosome : 21q22.3

Description of this Gene: ATP binding cassette subfamily G member 1

Type of Gene: protein-coding

rs4148112 in ABCG1 gene and AMYOTROPHIC LATERAL SCLEROSIS 1 PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs4148112 in ABCG1 gene and AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs4148112 in ABCG1 gene and AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs4148112 in ABCG1 gene and Amyotrophic Lateral Sclerosis, Sporadic PMID 24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.

rs914189 in ABCG1 gene and Arthritis, Gouty PMID 22179738 2012 Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

rs4148087 in ABCG1 gene and Bipolar Disorder PMID 26433762 2016 A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

rs4148087 in ABCG1 gene and Eating Disorders PMID 26433762 2016 A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

rs914189 in ABCG1 gene and Gout PMID 22179738 2012 Gout and type 2 diabetes have a mutual inter-dependent effect on genetic risk factors and higher incidences.

rs4148087 in ABCG1 gene and Other eating disorders PMID 26433762 2016 A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

rs170444 in ABCG1 gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs170444 in ABCG1 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.