Gene: ACSL6

Alternate names for this Gene: ACS2|FACL6|LACS 6|LACS2|LACS5

Gene Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: acyl-CoA synthetase long chain family member 6

Type of Gene: protein-coding

rs476428 in ACSL6 gene and Alzheimer's Disease PMID 25778476 2016 A novel Alzheimer disease locus located near the gene encoding tau protein.