Gene: ADCY2

Alternate names for this Gene: AC2|HBAC2

Gene Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.

Gene is located in Chromosome: 5

Location in Chromosome : 5p15.31

Description of this Gene: adenylate cyclase 2

Type of Gene: protein-coding

rs7704053 in ADCY2 gene and Adolescent idiopathic scoliosis PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs2451828 in ADCY2 gene and Anxiety Disorders PMID 31116379 2019 Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.

rs58502974 in ADCY2 gene and Attention deficit hyperactivity disorder PMID 27890468 2017 Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

rs10512928 in ADCY2 gene and Bipolar Disorder PMID 24618891 2014 Genome-wide association study reveals two new risk loci for bipolar disorder.

PMID 27890468 2017 Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

rs6555474 in ADCY2 gene and Fasting blood glucose measurement PMID 19060907 2009 Variants in MTNR1B influence fasting glucose levels.

rs78277363 in ADCY2 gene and Impaired cognition PMID 26252872 2015 Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.

rs17826816 in ADCY2 gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

rs34043481 in ADCY2 gene and Low density lipoprotein cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs7704053 in ADCY2 gene and SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 PMID 30019117 2018 The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.

rs34043481 in ADCY2 gene and Serum LDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.