Gene: ADH4

Alternate names for this Gene: ADH-2|HEL-S-4

Gene Summary: This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.

Gene is located in Chromosome: 4

Location in Chromosome : 4q23

Description of this Gene: alcohol dehydrogenase 4 (class II), pi polypeptide

Type of Gene: protein-coding

Gene: LOC100507053

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 4

Location in Chromosome : 4q23

Description of this Gene: uncharacterized LOC100507053

Type of Gene: ncRNA

rs5860563 in ADH4;LOC100507053 gene and Alcohol-Induced Disorders PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs5860563 in ADH4;LOC100507053 gene and Alcohol-Related Disorders PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs5860563 in ADH4;LOC100507053 gene and Alcoholic Intoxication, Chronic PMID 30940813 2019 Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

rs4699720 in ADH4;LOC100507053 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs3805322 in ADH4;LOC100507053 gene and Esophageal Neoplasms PMID 20833657 2010 Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.

PMID 22960999 2012 Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.

rs1042365 in ADH4;LOC100507053 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.