Gene: AKR1B10

Alternate names for this Gene: AKR1B11|AKR1B12|ALDRLn|ARL-1|ARL1|HIS|HSI

Gene Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Gene is located in Chromosome: 7

Location in Chromosome : 7q33

Description of this Gene: aldo-keto reductase family 1 member B10

Type of Gene: protein-coding

rs1722886 in AKR1B10 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs2347377 in AKR1B10 gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs2347377 in AKR1B10 gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs706159 in AKR1B10 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.