Gene: ALDH1A2

Alternate names for this Gene: RALDH(II)|RALDH2|RALDH2-T

Gene Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.

Gene is located in Chromosome: 15

Location in Chromosome : 15q21.3

Description of this Gene: aldehyde dehydrogenase 1 family member A2

Type of Gene: protein-coding

Gene: LIPC-AS1

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

Location in Chromosome :

Description of this Gene:

Type of Gene:

Gene: LIPC

Alternate names for this Gene: HDLCQ12|HL|HTGL|LIPH

Gene Summary: LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

Gene is located in Chromosome: 15

Location in Chromosome : 15q21.3

Description of this Gene: lipase C, hepatic type

Type of Gene: protein-coding

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Atrial Fibrillation PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Body mass index PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Cardiovascular Diseases PMID 18179892 2008 Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Cerebrovascular accident PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Coronary heart disease PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Diabetes PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Diabetes Mellitus PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Diastolic blood pressure PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Glucose measurement PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Heart failure PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Hematocrit procedure PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Hemoglobin measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and High density lipoprotein measurement PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

PMID 29615537 2018 Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Malignant Neoplasms PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Serum total cholesterol measurement PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

PMID 29615537 2018 Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.

PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Systolic Pressure PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

rs261332 in ALDH1A2;LIPC-AS1;LIPC gene and elevated blood glucose level PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.