Gene: AP2A2

Alternate names for this Gene: ADTAB|CLAPA2|HIP-9|HIP9|HYPJ

Gene Summary: The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: adaptor related protein complex 2 subunit alpha 2

Type of Gene: protein-coding

rs10751667 in AP2A2 gene and Alzheimer's Disease PMID 24162737 2013 Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

rs7104956 in AP2A2 gene and Asthma PMID 27611488 2017 Identification of Four Novel Loci in Asthma in European American and African American Populations.