Gene: APH1B
Alternate names for this Gene: APH-1B|PRO1328|PSFL|TAAV688
Gene Summary: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein.
Gene is located in Chromosome: 15
Location in Chromosome : 15q22.2
Description of this Gene: aph-1 homolog B, gamma-secretase subunit
Type of Gene: protein-coding