Gene: ARHGAP15

Alternate names for this Gene: BM046

Gene Summary: RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF217507.1, AY219338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295095.11/ ENSP00000295095.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

Gene is located in Chromosome: 2

Location in Chromosome : 2q22.2-q22.3

Description of this Gene: Rho GTPase activating protein 15

Type of Gene: protein-coding

rs74847330 in ARHGAP15 gene and Allergic Reaction PMID 29083406 2017 Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.

rs13002158 in ARHGAP15 gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs35125029 in ARHGAP15 gene and Circadian Rhythms PMID 26835600 2016 GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.

rs13010737 in ARHGAP15 gene and Coronary Artery Disease PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

rs2034604 in ARHGAP15 gene and Developmental absence of tooth PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs10189773 in ARHGAP15 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 17463246 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

rs7606205 in ARHGAP15 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs4662344 in ARHGAP15 gene and Diverticular Diseases PMID 28585551 2017 In the combined Icelandic and Danish data sets we observe significant association of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 × 10<sup>-18</sup>, odds ratio (OR)=1.23) and COLQ (collagen-like tail subunit of asymmetric acetylcholinesterase; rs7609897-T: P=1.5 × 10<sup>-10</sup>, OR=0.87) with diverticular disease and in FAM155A (family with sequence similarity 155A; rs67153654-A: P=3.0 × 10<sup>-11</sup>, OR=0.82) with diverticulitis.

PMID 30661054 2019 Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms.

PMID 30177863 2018 Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.

rs4662344 in ARHGAP15 gene and Diverticulitis PMID 28585551 2017 In the combined Icelandic and Danish data sets we observe significant association of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 × 10<sup>-18</sup>, odds ratio (OR)=1.23) and COLQ (collagen-like tail subunit of asymmetric acetylcholinesterase; rs7609897-T: P=1.5 × 10<sup>-10</sup>, OR=0.87) with diverticular disease and in FAM155A (family with sequence similarity 155A; rs67153654-A: P=3.0 × 10<sup>-11</sup>, OR=0.82) with diverticulitis.

rs16858573 in ARHGAP15 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs79716587 in ARHGAP15 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2034604 in ARHGAP15 gene and Hypodontia PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs2034604 in ARHGAP15 gene and Hypodontia Oligodontia with Orofacial Cleft PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs10189912 in ARHGAP15 gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

PMID 29186694 2017 Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.

PMID 28530673 2017 Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.

PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

PMID 29520040 2019 Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.

PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs140397066 in ARHGAP15 gene and Lymphocyte Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs13413953 in ARHGAP15 gene and Major Depressive Disorder PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs13413953 in ARHGAP15 gene and Mood Disorders PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

rs2034604 in ARHGAP15 gene and Oligodontia PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs74847330 in ARHGAP15 gene and Platelet Component Distribution Width Measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs74847330 in ARHGAP15 gene and Platelet mean volume determination (procedure) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs4273169 in ARHGAP15 gene and Schizophrenia PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs2034604 in ARHGAP15 gene and TOOTH AGENESIS, SELECTIVE, 9 PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs2034604 in ARHGAP15 gene and Tooth Agenesis, Familial PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs2034604 in ARHGAP15 gene and Tooth Agenesis, Selective, With Orofacial Cleft PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs2034604 in ARHGAP15 gene and Tooth development and eruption disorder PMID 29364747 2018 Rare and Common Variants Conferring Risk of Tooth Agenesis.

rs141234028 in ARHGAP15 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs12991555 in ARHGAP15 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.