Gene: ARHGEF2

Alternate names for this Gene: GEF|GEF-H1|GEFH1|LFP40|Lfc|NEDMHM|P40

Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene is located in Chromosome: 1

Location in Chromosome : 1q22

Description of this Gene: Rho/Rac guanine nucleotide exchange factor 2

Type of Gene: protein-coding

rs2364403 in ARHGEF2 gene and Amyotrophic Lateral Sclerosis PMID 22959728 2013 Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.