Gene: ARHGEF28

Alternate names for this Gene: RGNEF|RIP2|p190RHOGEF

Gene Summary: This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.

Gene is located in Chromosome: 5

Location in Chromosome : 5q13.2

Description of this Gene: Rho guanine nucleotide exchange factor 28

Type of Gene: protein-coding

rs6881956 in ARHGEF28 gene and High density lipoprotein measurement PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs7714670 in ARHGEF28 gene and Venous Thromboembolism PMID 23509962 2013 A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.