Gene: ASCL2

Alternate names for this Gene: ASH2|HASH2|MASH2|bHLHa45

Gene Summary: This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: achaete-scute family bHLH transcription factor 2

Type of Gene: protein-coding

rs116549635 in ASCL2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.