Gene: ATG16L1
Alternate names for this Gene: APG16L|ATG16A|ATG16L|IBD10|WDR30
Gene Summary: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 2
Location in Chromosome : 2q37.1
Description of this Gene: autophagy related 16 like 1
Type of Gene: protein-coding
rs36001488 in
ATG16L1 gene and
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs36001488 in
ATG16L1 gene and
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs36001488 in
ATG16L1 gene and
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs35300242 in
ATG16L1 gene and
Ankylosing spondylitis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs3828309 in
ATG16L1 gene and
Asthma
PMID 21150878 2011 Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
rs36001488 in
ATG16L1 gene and
Autoimmune Diseases
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs36001488 in
ATG16L1 gene and
Autoimmune thyroiditis
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs2083575 in
ATG16L1 gene and
Bilirubin level result
PMID 19414484 2009 Genome-wide association meta-analysis for total serum bilirubin levels.
rs2083575 in
ATG16L1 gene and
Bilirubin measurement
PMID 19414484 2009 Genome-wide association meta-analysis for total serum bilirubin levels.
PMID 31319653 2019 A total of 5 genetic variants-TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)-were selected as genetic instruments for serum bilirubin levels using a communitybased cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects.
rs36001488 in
ATG16L1 gene and
Celiac Disease
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs35300242 in
ATG16L1 gene and
Cholangitis, Sclerosing
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs36001488 in
ATG16L1 gene and
Common Variable Immunodeficiency
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs10210302 in
ATG16L1 gene and
Crohn Disease
PMID 17554300 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
PMID 23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
PMID 18587394 2008 Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
PMID 28067908 2017 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
rs36001488 in
ATG16L1 gene and
Diabetes Mellitus, Insulin-Dependent
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs12994997 in
ATG16L1 gene and
Inflammatory Bowel Diseases
PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
PMID 28067908 2017 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
rs36001488 in
ATG16L1 gene and
Juvenile arthritis
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs36001488 in
ATG16L1 gene and
Lupus Erythematosus, Systemic
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs3828309 in
ATG16L1 gene and
Multiple Sclerosis
PMID 22190364 2011 Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
rs35300242 in
ATG16L1 gene and
Psoriasis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
rs35300242 in
ATG16L1 gene and
Ulcerative Colitis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PMID 26301688 2015 Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.