Gene: BRAP

Alternate names for this Gene: BRAP2|IMP|RNF52

Gene Summary: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.

Gene is located in Chromosome: 12

Location in Chromosome : 12q24.12

Description of this Gene: BRCA1 associated protein

Type of Gene: protein-coding

rs3782886 in BRAP gene and Alanine aminotransferase measurement PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs3782886 in BRAP gene and Alcohol consumption PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

rs11066001 in BRAP gene and Alcohol-Induced Disorders PMID 31591379 2019 Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.

rs11066001 in BRAP gene and Alcohol-Related Disorders PMID 31591379 2019 Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.

rs11066001 in BRAP gene and Alcoholic Intoxication, Chronic PMID 31591379 2019 Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.

PMID 24277619 2014 "ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."

rs10744775 in BRAP gene and C-reactive protein measurement PMID 27286809 2016 Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

rs11066001 in BRAP gene and Coronary heart disease PMID 21971053 2012 Genome-wide association study of coronary artery disease in the Japanese.

PMID 23364394 2013 A genome-wide association study of a coronary artery disease risk variant.

rs10744773 in BRAP gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.

rs3782886 in BRAP gene and Drinking behavior processes PMID 23364009 2013 Common variants at 12q24 are associated with drinking behavior in Han Chinese.

PMID 21372407 2011 Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.

rs3782886 in BRAP gene and Folic acid measurement PMID 29953918 2018 Surprisingly, we discovered three novel loci rs3782886, rs671, and rs4646776 of ALDH2 gene were suggestively significantly associated with folate serum folate levels in the male population studied (P = 2.17 × 10<sup>-7</sup>, P = 3.60 × 10<sup>-7</sup>, P = 3.99 × 10<sup>-7</sup>, respectively) after adjusting for population stratification, BMI and age.

rs3782886 in BRAP gene and Hepatitis B PMID 21750111 2011 A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.

rs10744775 in BRAP gene and Low density lipoprotein cholesterol measurement PMID 27286809 2016 Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation.

rs11066001 in BRAP gene and Malignant neoplasm of esophagus PMID 21642993 2011 Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

rs3782886 in BRAP gene and Myocardial Infarction PMID 24916648 2015 A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.

PMID 21107343 2011 SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population.

rs749237684 in BRAP gene and Platelet Count measurement PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs3782886 in BRAP gene and Serum Alanine Aminotransferase Measurement PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs3782886 in BRAP gene and Uric acid measurement (procedure) PMID 29124443 2018 Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.