Gene: C11orf21

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: chromosome 11 open reading frame 21

Type of Gene: protein-coding

Gene: TSPAN32

Alternate names for this Gene: ART1|PHEMX|PHMX|TSSC6

Gene Summary: This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.5

Description of this Gene: tetraspanin 32

Type of Gene: protein-coding

rs188839109 in C11orf21;TSPAN32 gene and Bipolar Disorder PMID 29064472 2017 Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

rs2651823 in C11orf21;TSPAN32 gene and Chronic Lymphocytic Leukemia PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

rs16928078 in C11orf21;TSPAN32 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs16928078 in C11orf21;TSPAN32 gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs1501466 in C11orf21;TSPAN32 gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs16928078 in C11orf21;TSPAN32 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs188839109 in C11orf21;TSPAN32 gene and Schizoaffective Disorder PMID 29064472 2017 Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

rs188839109 in C11orf21;TSPAN32 gene and Schizophrenia PMID 29064472 2017 Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

rs2651823 in C11orf21;TSPAN32 gene and Small Lymphocytic Lymphoma PMID 28165464 2017 Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

rs16928078 in C11orf21;TSPAN32 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.