Gene: CCHCR1

Alternate names for this Gene: C6orf18|HCR|SBP|pg8

Gene Summary: This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: coiled-coil alpha-helical rod protein 1

Type of Gene: protein-coding

rs1265115 in CCHCR1 gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs1265115 in CCHCR1 gene and AIDS, PROGRESSION TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs130065 in CCHCR1 gene and Asthma PMID 20860503 2010 A large-scale, consortium-based genomewide association study of asthma.

rs2073716 in CCHCR1 gene and Behcet Syndrome PMID 23001997 2012 Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

rs115321690 in CCHCR1 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

rs130078 in CCHCR1 gene and Graves Disease PMID 21900946 2011 Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.

rs1265115 in CCHCR1 gene and HIV-1, RESISTANCE TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs1265115 in CCHCR1 gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 21051598 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

rs1265115 in CCHCR1 gene and Hepatitis B PMID 23760081 2013 A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.

rs2240064 in CCHCR1 gene and Hodgkin Disease PMID 24149102 2013 Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.

rs130067 in CCHCR1 gene and Malignant neoplasm of prostate PMID 21743467 2011 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

rs2240060 in CCHCR1 gene and Microalbuminuria PMID 31511532 2019 Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

rs3132535 in CCHCR1 gene and Multiple Myeloma PMID 27363682 2016 Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

rs130067 in CCHCR1 gene and Prostate carcinoma PMID 21743467 2011 Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

rs1576 in CCHCR1 gene and Psoriasis PMID 30921485 2019 Genome-wide association study of psoriasis in an Egyptian population.

rs1265110 in CCHCR1 gene and Rheumatoid Arthritis PMID 17804836 2007 TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

rs9263739 in CCHCR1 gene and Ulcerative Colitis PMID 19915573 2009 A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.

rs130065 in CCHCR1 gene and Vitiligo PMID 20526339 2010 Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.