Gene: CD44

Alternate names for this Gene: CDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1

Gene Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

Gene is located in Chromosome: 11

Location in Chromosome : 11p13

Description of this Gene: CD44 molecule (Indian blood group)

Type of Gene: protein-coding

rs7116432 in CD44 gene and Fasting blood glucose measurement PMID 31021400 2019 Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.

rs353616 in CD44 gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs112762 in CD44 gene and NEPHROLITHIASIS, CALCIUM OXALATE PMID 24886237 2014 A whole genome SNP genotyping by DNA microarray and candidate gene association study for kidney stone disease.

rs353616 in CD44 gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs12275533 in CD44 gene and Serum total cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs11033026 in CD44 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.