Gene: CD80
Alternate names for this Gene: B7|B7-1|B7.1|BB1|CD28LG|CD28LG1|LAB7
Gene Summary: The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
Gene is located in Chromosome: 3
Location in Chromosome : 3q13.33
Description of this Gene: CD80 molecule
Type of Gene: protein-coding
rs2222631 in
CD80 gene and
Lupus Erythematosus, Systemic
PMID 25862617 2016 Single nuclear polymorphism rs2222631 was found associated with SLE with genome-wide significance (P_all=4.5E-08, OR=0.86) and is independent of rs6804441 in CD80, whose association was reported previously.
PMID 23273568 2013 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.