Gene: CDC25A

Alternate names for this Gene: CDC25A2

Gene Summary: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: cell division cycle 25A

Type of Gene: protein-coding

rs146179438 in CDC25A gene and High density lipoprotein measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.