Gene: CDC25B

Alternate names for this Gene: -

Gene Summary: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.

Gene is located in Chromosome: 20

Location in Chromosome : 20p13

Description of this Gene: cell division cycle 25B

Type of Gene: protein-coding

rs3761218 in CDC25B gene and Bipolar Disorder PMID 21254220 2011 Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.

rs4815606 in CDC25B gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4815605 in CDC25B gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.