Gene: CHADL
Alternate names for this Gene: SLRR4B
Gene Summary:
Gene is located in Chromosome: 22
Location in Chromosome : 22q13.2
Description of this Gene: chondroadherin like
Type of Gene: protein-coding
rs532464664 in
CHADL gene and
Degenerative polyarthritis
PMID 28319091 2017 We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 × 10<sup>-12</sup>, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 × 10<sup>-18</sup>, OR = 7.71).
rs532464664 in
CHADL gene and
Osteoarthritis of hip
PMID 30374069 2018 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
rs532464664 in
CHADL gene and
Osteoarthritis, Knee
PMID 30374069 2018 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.