Gene: CORIN

Alternate names for this Gene: ATC2|CRN|Lrp4|PEE5|TMPRSS10

Gene Summary: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 4

Location in Chromosome : 4p12

Description of this Gene: corin, serine peptidase

Type of Gene: protein-coding

rs16860432 in CORIN gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs387906894 in CORIN gene and PREECLAMPSIA/ECLAMPSIA 5 PMID 22437503 2012 Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.

rs16860432 in CORIN gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs4695266 in CORIN gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.