Gene: CRLF2
Alternate names for this Gene: CRL2|CRLF2Y|TSLPR
Gene Summary: This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Gene is located in Chromosome: X|Y
Location in Chromosome : X;Y
Description of this Gene: cytokine receptor like factor 2
Type of Gene: protein-coding
rs1057519743 in
CRLF2 gene and
Acute lymphoblastic leukemia with lymphomatous features
PMID 22368272 2012 Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.
PMID 19907440 2010 Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia.
PMID 20018760 2010 Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
PMID 19965641 2010 Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.