Condition: Acute lymphoblastic leukemia with lymphomatous features


rs121913459 in ABL1 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 11861307 2002 Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 22772060 2013 MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia.

PMID 18615627 2008 Kinase domain point mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia emerge after therapy with BCR-ABL kinase inhibitors.

PMID 11853795 2002 BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study.

rs1057519743 in CRLF2 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 22368272 2012 Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study.

PMID 19907440 2010 Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia.

PMID 20018760 2010 Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.

PMID 19965641 2010 Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.

rs1057519897 in FGFR1 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs1057519759 in IL7R gene and Acute lymphoblastic leukemia with lymphomatous features PMID 22955920 2012 Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

PMID 22897847 2012 Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.

rs1057519721 in INSL6;JAK2 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 19470474 2009 JAK mutations in high-risk childhood acute lymphoblastic leukemia.

PMID 22368270 2012 Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.

PMID 18805579 2008 Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome.

PMID 22955920 2012 Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

rs1057519753 in JAK1 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 19470474 2009 JAK mutations in high-risk childhood acute lymphoblastic leukemia.

PMID 19139102 2009 Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.

PMID 21680795 2011 Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

PMID 19838194 2009 Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.

PMID 22955920 2012 Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

PMID 20167706 2010 ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon.

rs1057519722 in JAK2;INSL6 gene and Acute lymphoblastic leukemia with lymphomatous features PMID 18805579 2008 Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome.

PMID 22955920 2012 Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

PMID 22368270 2012 Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.

PMID 19470474 2009 JAK mutations in high-risk childhood acute lymphoblastic leukemia.