Gene: CYCS

Alternate names for this Gene: CYC|HCS|THC4

Gene Summary: This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.

Gene is located in Chromosome: 7

Location in Chromosome : 7p15.3

Description of this Gene: cytochrome c, somatic

Type of Gene: protein-coding

rs1861525 in CYCS gene and Alzheimer's Disease PMID 23535033 2014 Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

rs121918552 in CYCS gene and Thrombocytopenia PMID 31064749 2019 Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders.

rs121918552 in CYCS gene and Thrombocytopenia 4 PMID 18345000 2008 A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.