Gene: CYP2A6

Alternate names for this Gene: CPA6|CYP2A|CYP2A3|CYPIIA6|P450C2A|P450PB

Gene Summary: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.2

Description of this Gene: cytochrome P450 family 2 subfamily A member 6

Type of Gene: protein-coding

rs56113850 in CYP2A6 gene and Adenocarcinoma of lung (disorder) PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

rs56113850 in CYP2A6 gene and Carcinoma of lung PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

rs56113850 in CYP2A6 gene and Forced expiratory volume function PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

rs56113850 in CYP2A6 gene and Non-Small Cell Lung Carcinoma PMID 31326317 2019 Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.

rs56113850 in CYP2A6 gene and Smoking PMID 27488534 2016 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

rs56113850 in CYP2A6 gene and Smoking Behaviors PMID 27488534 2016 Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.

rs56113850 in CYP2A6 gene and Squamous cell carcinoma of lung PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

rs56113850 in CYP2A6 gene and response to bronchodilator PMID 26634245 2015 A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.