Gene: CYP2S1

Alternate names for this Gene: CYPIIS1

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.

Gene is located in Chromosome: 19

Location in Chromosome : 19q13.2

Description of this Gene: cytochrome P450 family 2 subfamily S member 1

Type of Gene: protein-coding

rs338598 in CYP2S1 gene and Nasal Polyps PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.