rs34210653 in
ALOX15 gene and
Nasal Polyps
PMID 30643255 2019 Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10<sup>-27</sup>, odds ratio = 0.32; 95% confidence interval = 0.26, 0.39) and CRS (P = 1.1 × 10<sup>-8</sup>, odds ratio = 0.64; 95% confidence interval = 0.55, 0.75). p.Thr560Met, carried by around 1 in 20 Europeans, was previously shown to cause near total loss of 15-LO enzymatic activity.
rs62408225 in
BACH2 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs338598 in
CYP2S1 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs17718444 in
FOXP1 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs10905284 in
GATA3 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs4807542 in
GPX4 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs2428494 in
HLA-B gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs1391371 in
HLA-DQA1 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs6543124 in
IL18R1 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs1420101 in
IL1RL1;IL18R1 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs174535 in
MYRF;TMEM258 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs1050152 in
SLC22A4;MIR3936HG gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.