Gene: DCHS2

Alternate names for this Gene: CDH27|CDHJ|CDHR7|PCDH23|PCDHJ

Gene Summary: This gene encodes a large protein that contains many cadherin domains and likely functions in cell adhesion. Genome-wide association studies suggest that this gene may be important in Alzheimer's disease, compressive strength index, and appendicular lean mass.

Gene is located in Chromosome: 4

Location in Chromosome : 4q31.3

Description of this Gene: dachsous cadherin-related 2

Type of Gene: protein-coding

rs12500118 in DCHS2 gene and Alzheimer's Disease PMID 22005931 2012 Genome-wide association analysis of age-at-onset in Alzheimer's disease.

rs17031671 in DCHS2 gene and Bilirubin measurement PMID 20639394 2010 Genome-wide association of serum bilirubin levels in Korean population.

rs902464 in DCHS2 gene and Cytokine Measurement PMID 22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

rs12651106 in DCHS2 gene and Fibrinogen assay PMID 21757653 2011 Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.

rs12651106 in DCHS2 gene and Fibrinogen, CTCAE PMID 21757653 2011 Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.

rs1352714 in DCHS2 gene and Graves Disease PMID 31050781 2019 Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study.

rs1352714 in DCHS2 gene and Thyrotoxic periodic paralysis PMID 31050781 2019 Two new TPP-specific susceptibility loci were identified: DCHS2 on 4q31.3 (rs1352714: odds ratio [OR], 1.58; 95% CI, 1.35-1.85; P = 1.24 × 10-8) and C11orf67 on 11q14.1 (rs2186564: OR, 1.50; 95% CI, 1.29-1.74; P = 2.80 × 10-7).

rs12651106 in DCHS2 gene and fibrinogen activity PMID 21757653 2011 Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.