Gene: DGKD

Alternate names for this Gene: DGK-delta|DGKdelta|dgkd-2

Gene Summary: This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.1

Description of this Gene: diacylglycerol kinase delta

Type of Gene: protein-coding

rs1053895 in DGKD gene and Bilirubin level result PMID 19414484 2009 Genome-wide association meta-analysis for total serum bilirubin levels.

PMID 19419973 2009 Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

rs1053895 in DGKD gene and Bilirubin measurement PMID 19414484 2009 Genome-wide association meta-analysis for total serum bilirubin levels.

PMID 20639394 2010 Genome-wide association of serum bilirubin levels in Korean population.

PMID 19419973 2009 Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

rs838721 in DGKD gene and Bone Density PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

rs1550532 in DGKD gene and Calcium level result PMID 24068962 2013 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

rs1550532 in DGKD gene and Calcium measurement PMID 24068962 2013 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs838720 in DGKD gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

rs34339006 in DGKD gene and Glaucoma, Open-Angle PMID 29891935 2018 A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

rs11694406 in DGKD gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.