Gene: DGKG
Alternate names for this Gene: DAGK3|DGK-GAMMA
Gene Summary: This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene is located in Chromosome: 3
Location in Chromosome : 3q27.2-q27.3
Description of this Gene: diacylglycerol kinase gamma
Type of Gene: protein-coding
rs7647305 in
DGKG gene and
Body Weight
PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
rs7647305 in
DGKG gene and
Body mass index
PMID 28430825 2017 Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.
PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
rs7647305 in
DGKG gene and
Body mass index procedure
PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
rs7647305 in
DGKG gene and
Finding of body mass index
PMID 19079260 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
PMID 20935630 2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
PMID 23001569 2013 Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.
rs7648566 in
DGKG gene and
Forced expiratory volume function
PMID 26423011 2015 Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.
rs2268840 in
DGKG gene and
High density lipoprotein measurement
PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.
rs11924809 in
DGKG gene and
Major Depressive Disorder
PMID 27622933 2016 Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.
rs11924809 in
DGKG gene and
Mood Disorders
PMID 27622933 2016 Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.
rs9816226 in
DGKG gene and
Obesity
PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
rs7647305 in
DGKG gene and
Physical Activity Measurement
PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
rs11924809 in
DGKG gene and
Unipolar Depression
PMID 27622933 2016 Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.
rs7647305 in
DGKG gene and
Waist-Hip Ratio
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.