Gene: DKK2

Alternate names for this Gene: DKK-2

Gene Summary: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Gene is located in Chromosome: 4

Location in Chromosome : 4q25

Description of this Gene: dickkopf WNT signaling pathway inhibitor 2

Type of Gene: protein-coding

rs4109346 in DKK2 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs78311490 in DKK2 gene and Alopecia, Androgenetic, 1 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs78311490 in DKK2 gene and Alopecia, Androgenetic, 2 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs78311490 in DKK2 gene and Alopecia, Androgenetic, 3 PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs78311490 in DKK2 gene and Alopecia, Male Pattern PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs78311490 in DKK2 gene and Androgenetic Alopecia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs77571736 in DKK2 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs116671518 in DKK2 gene and Epstein-Barr Virus Infections PMID 28654678 2017 Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.

rs78311490 in DKK2 gene and Other alopecia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.