Gene: DNAJB4

Alternate names for this Gene: DNAJW|DjB4|HLJ1

Gene Summary: The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: DnaJ heat shock protein family (Hsp40) member B4

Type of Gene: protein-coding

Gene: GIPC2

Alternate names for this Gene: SEMCAP-2|SEMCAP2

Gene Summary:

Gene is located in Chromosome: 1

Location in Chromosome : 1p31.1

Description of this Gene: GIPC PDZ domain containing family member 2

Type of Gene: protein-coding

rs34517439 in DNAJB4;GIPC2 gene and Adenocarcinoma of lung (disorder) PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

rs34517439 in DNAJB4;GIPC2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs34517439 in DNAJB4;GIPC2 gene and Body mass index PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs34517439 in DNAJB4;GIPC2 gene and Carcinoma of lung PMID 28604730 2017 Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

rs34517439 in DNAJB4;GIPC2 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs34517439 in DNAJB4;GIPC2 gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs34517439 in DNAJB4;GIPC2 gene and Psoriasis PMID 28537254 2017 Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.